Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Dental Pharmacology
岡山大学学術研究院医歯薬学域歯科薬理学分野
Principal Investigators and faculties
Kuniaki Okamoto, DDS, PhD
investigating cellular protein transport system controlled by Rab family and osteoblasts, key cells in periodontal diseases and osteoporosis.
Takanori Eguchi, DDS, PhD
investigating cells, bodies, and cancers regulated by molecular functions and transport through extracellular vesicles including exosomes.
Katsuki Takebe, DDS, PhD
investigating protein structures, interaction, and functions in medicine, dentistry and pharmaceutical sciences.
MISEV2023: the international guideline for EV research
Top Articles
analyzed by Elsevier SciVal in 2024 Jan
Top 1% article
Sheta M et al, Eguchi T*. Extracellular vesicles: new classification and tumor immunosuppression. Biology (Basel) 2023, 12(1):110.
Top 2% articles
Ono K et al, Eguchi T*.Triple Knockdown of CDC37, HSP90-alpha and HSP90-beta Diminishes Extracellular Vesicles-Driven Malignancy Events and Macrophage M2 Polarization in Oral Cancer.Journal of Extracellular Vesicles 2020, 9(1):1769373.
(2020 Journal Impact Factor = 25.841)
Ono K, Eguchi T*, et al. HSP-Enriched Properties of Extracellular Vesicles Involve Survival of Metastatic Oral Cancer Cells. Journal of Cellular Biochemistry 2018, 119(9):7363-76. > 150 citations
(2022). Methods in Molecular Biology, vol 2582. Humana, New York, NY. pp.59-76.
Top 3% articles
(2021 Journal Impact Factor = 17.012)
Eguchi T* et al. Organoids with Cancer Stem Cell-like Properties Secrete Exosomes and HSP90 in a 3D Nanoenvironment. PLoS One 2018,13(2):e0191109. > 100 citations
Top 4% articles
Oo MW et al. Resident Stroma-secreted Chemokine CCL2 Governs Myeloid-derived Suppressor Cells in the Tumor Microenvironment. JCI Insight, 2022,7(1);e148960
(2021 Journal Impact Factor = 9.533)
Seyama M et al, Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver. Biochimica et Biophysica Acta – Molecular Basis of Disease 2020,1866(6):165731
Research Themes
Research and development of exosomes, other vesicles, and delivery systems
Development and applications of assay and screening systems for diseases and regeneration
Research and development on cancer, tumor microenvironment and immunology
Research and development on cell differentiation and bone metabolism
Research and development of protein and drug functions based on structural biology and computational science
Drug discovery and development for therapeutics and diagnostics
Mechanisms and solution of drug resistance
Research and development on organoids, cancer-on-a-chip, and bone-on-a-chip
Research and development on metabolism, stress, and RNA regulation
Research and development on cancer-specific aberration and tumor immunology
Research and development on protease function and inhibition
Construction and utilization of databases and portals
研究課題
エクソソーム等の小胞とデリバリーシステムに関する研究開発
疾患や再生に関わるアッセイ系やスクリーニング系の開発と利活用
がんと微小環境に関する研究開発
細胞分化と骨代謝に関する研究開発
構造生物学および計算科学に基づくタンパク質と薬剤の機能に関する研究開発
治療薬や診断薬などの創薬に関する研究開発
薬剤耐性の機構および解決に関する研究開発
オルガノイド，癌チップ，骨チップに関する研究開発
代謝，ストレス，RNA制御に関する研究開発
がん特有の異常および腫瘍免疫に関する研究開発
プロテアーゼの機能と阻害に関する研究開発
データベースとポータルの構築と利活用に関する研究
Voice of students
It's truly heartwarming (｡･ω･｡)ﾉ.
I will channel my energy into designing experiments and start my research with peaceful mood, which brings me a sense of creativity and a desire for exploration.
We can collaborate more in the future.
Okayama is a beautiful city, and both I and my lab friends thoroughly enjoy our research and daily life here.
I am looking forward to the coming Spring with sakura blossoms blooming.
I hope everything is going smoothly for you, and wish you good health and happiness.
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PROJECTS
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VOICE OF A STUDENT
Vesicle Transport
Vesicle Transport
Experience
Bone Metabolism
Osteoclast
Exosome, Extracellular Vesicles
Excursion
MIcroenvironment
Presentation
Intercellular Communication
Environment
Organoid
Informatics
Research
Education
Experiments